慶應医学会例会

下記のとおり例会を開催いたしますので、ふるってご来聴くださいますようお願い申し上げます。

日 時 2017 年 10 月 3 日 (火) 16 : 30
場 所 総合医科学研究棟5階 会議室5
演 題 Form Follows Function: Systems Ecology of the Human Gut Microbiome
  Paul Wilmes Dr.
Luxembourg Centre for Systems Biomedicine, University of Luxembourg
担 当

微生物学・免疫学教室 教室
責任者:本田賢也 教授
担当者:(内線 62696)

 
  以上
日 時 2017 年 9 月 11 日 (月) 19 : 00
場 所 総合医科学研究棟1階 ラウンジ
演 題 Stem Cells and Genomics for Precision Cardiovascular Medicine
  Joseph C Wu MD, PhD, Professor
Stanford University
担 当

内科学(循環器)教室
責任者:福田恵一 教授
担当者:福田恵一 先生 (内線 61420)

 
  以上
日 時 2017 年 9 月 1 日 (金) 17 : 00
場 所 総合医科学研究棟1階 ラウンジ
演 題 Checkpoint inhibition in melanoma and solid tumors: - What has it taught us about the efficacy and side effects of immunotherapy for cancer?
  Jeffrey S Weber MD, PhD
Deputy Director, Laura and Isaac Perlmutter Cacncer Center, Professor of Medicine, NYU Langone Medical Center
担 当

先端研(細胞)教室
責任者:河上 裕 教授
担当者:(内線 62708)

 
  以上
日 時 2017 年 7 月 19 日 (水) 18 : 30
場 所 3号館北棟1階ラウンジ
演 題 Stroke and the cell therapy saga: towards a safe, swift and efficient utilization of cells
  Nathalie Kubis, MD,PhD

The first clinical trials of cell therapy in stroke were first published in the 2000s and consisted of neural stems cells transplanted via the intracerebral pathway. Since mesenchymal stem cells showed similar capacities to differentiate into neural cells and allowed autologous cell transplantation, they were then preferentially studied, including diabetes and hypertension. More recently, bone marrow derived mononuclear cells were successfully transplanted in stroke with no need of culture processing, and simple collection by density gradient centrifugation rendering them immediately ready for use. They improve post-stroke neurological deficit in rodents and clinical trials have shown the feasibility of intra-arterial or intravenous administration. The underlying mechanisms are not yet understood. We investigated the therapeutic potential of peripheral blood derived mononuclear cells (PB-MNC) harvested from diabetic patients and stimulated by ephrin-B2 (PB-MNC+). We showed that intravenously injected PB-MNC+ after cerebral ischemia reduced infarct volume at day 3, increased cell proliferation in the peri-infarct area and the subventricular zone, decreased microglial cell density, and upregulated TGF-β expression. At D14, microvessel density was increased and functional recovery enhanced, whereas plasma levels of BDNF were increased in treated mice. Ephrin-B2 induced phenotype switching of PB-MNC by upregulating genes controlling cell proliferation, inflammation and angiogenesis, as confirmed by adhesion and Matrigel assays. PB-MNC+ transplantation in stroke is a promising approach and should be investigated for the development of rapid, non-invasive bedside cell therapy strategies in stroke.
担 当

内科学(神経)教室
責任者:鈴木則宏 教授 (内線 62303)
担当者:橋愼一 先生

  以上
日 時 2017 年 7 月 7 日 (金) 17 : 00〜
場 所 リサーチパーク1階ラウンジ
演 題 分岐鎖アミノ酸代謝と細胞運命制御
  伊藤 貴浩 先生
米国ジョージア大学 生化学・分子生物学部 助教授・講座主任

(要旨)
がん細胞は正常細胞とは異なる代謝活動を行うことが知られている。代謝リプログラミングと総称されるこの現象は、がん細胞の生存・分裂に必要なエネルギーの産生やタンパク質・核酸などの生体高分子の供給に重要であり、がんが体内で生き延びるための重要戦略のひとつと考えられるようになった。一方、良性腫瘍や前がん状態から悪性度の高いがんへと進行する過程で代謝リプログラミングが起こるのか、また機能的に重要なのかについては未だ明らかではない。
私たちは最近、慢性骨髄性白血病の悪性化に伴って分岐鎖アミノ酸(BCAA)の産生が亢進すること、アミノ酸代謝酵素BCAT1の発現が活性化することを見いだした。またBCAT1の機能阻害によりヒト白血病細胞の増殖およびマウスモデルでの白血病発症が阻止できることがわかった。
一方で、BCAT1は正常造血細胞には殆ど発現しておらず機能的にも必須ではなかった。これらの結果は、がん特異的なBCAT1活性化による代謝リプログラミングが白血病の進行を制御することを示している。造血器腫瘍以外のがんにおけるBCAA代謝経路の機能を含め、がん進行を抑止できる新たな治療標的としてのアミノ酸代謝経路の可能性について議論したい。

(参考文献)
Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison A, Ito T. Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia. Nature (2017)
Zimdahl B*, Ito T*, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet 46:245-52 (2014) Ito T*, Kwon HY*, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. Regulation of myeloid leukaemia by the cell fate determinant Musashi. Nature 466:765-8 (2010)
担 当 責任者:微生物学・免疫学教室 吉村 昭彦
連絡先:微生物学・免疫学教室 谷口 浩二 (内線61224)

  以上
日 時 2017 年 7 月 5 日 (水) 18 : 00
場 所 東校舎講堂
演 題 Precision Cancer Medicine and Super-computing System
  Toshifumi Wakai MD, PhD, FACS
Division of Digestive and General Surgery, Niigata University

Precision Cancer Medicine: Tumors are classified into several molecular subtypes by Genomic Sequencing. Comprehensive targeted-gene panel provides more therapeutic options. CANCERPLEX-JP version 4.0 includes 435 actionable genes, which clinical approaches are available. Utilizing the gene panel platform, we assessed the genes and pathways most frequently altered in Japanese and US cases (Genome Med 2016;8:136). We demonstrate concordance of CANCERPLEX-JP with whole-exome sequencing from the TCGA in identifying hypermutated samples and microsatellite instability in multiple cancer types, such as colorectal and gastric cancer. We introduced our activity for precision medicine at 4th US-Japan Clinical Trials in Oncology Workshop sponsored by Embassy of Japan, at Washington DC, held in June 9, 2016. We highlight the clinical utility of CANCERPLEX-JP (435 genes) in guiding treatment strategies with targeted therapy in solid tumors, thus providing rationale for Comprehensive Genomic Sequencing in actualizing precision medicine. The goal of Precision Medicine is cost effectiveness and realization of genome drug discovery.
Super-computing System: This introduction plan is based on the massive medical big data (cancer gene mutation information, genomic data, image data, etc.) possessed by Niigata Prefecture and Niigata University, to construct an integrated analysis system incorporating deep learning, and introduces a high-performance computer system for the development and activation of related industries. Therefore, it is necessary to have an operation system that can connect to the hospital electronic medical record without interference.

演 題 Leadership training of surgery in US
  Kazuaki Takabe M.D.
Alfiero Foundation Chair and Clinical Chief of Breast Surgery Leader of Breast Program and Breast Disease Site, Breast Oncology Fellowship Program Director, Roswell Park Cancer Institute

Surgeons in US receive training to be a leader during surgical residency, which is postgraduate education. Leadership is considered to be essential, since the surgeon directs the medical team. Every surgeons should get the opportunity to acquire the leadership skill. I would like to introduce the leadership training that I received as an ASCO Leadership Development Program graduate and as Geisel Leadership Course at Dartmouth Scholars in addition to the American Surgical Residency. I would also like to announce the research of Precision Medicine in my department.
担 当

外科学教室
責任者:北川雄光 教授 (内線 62334)

  以上
日 時 2017 年 7 月 4 日 (火) 10 : 00
場 所 東校舎1階会議室
演 題 In situ analysis of T cell migration within inflamed lungs
  Paulus Mrass M.D.PhD
Molecular Genetics and Microbiology University of New Mexico
担 当

微生物学・免疫学教室 教室
責任者:吉村昭彦 教授
担当者:(内線 61220)

  以上
日 時 2017 年 6 月 23 日 (金) 18 : 00-19 : 30
場 所 リサーチパークラウンジ
演 題 Microbiota-dependent tissue adaptation of intraepithelial CD4+ T lymphocytes
  Mariya London B.S.
The Rockefeller University(USA)

演 題 Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages.
  Ilana Gabanyi PhD
Pasteur Institute(France)

担 当

消化器内科 教室
責任者:金井 隆典 教授
担当者:筋野 智久 先生(内線 62384)

  以上
日 時 2017 年 6 月 5 日 (月) 18 : 00
場 所 総合医科学研究棟1階ラウンジ
演 題 Lipids in Immunology: antigens and regulators of immune responses
  Florian Winau MD
Department of Microbiology and Immunobiology, Harvard Medical School
担 当

皮膚科学 教室
責任者:天谷 雅行 教授
担当者:久保 亮治 先生(内線 62411)

  以上

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